Corticosteroids for pulmonary sarcoidosis

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Inhaled corticosteroids and pulmonary sarcoidosis.

Corticosteroids are the drugs of choice for treatment of sarcoidosis. Frequently the pulmonary parenchymal lesions with impaired lung function represent the indication for starting treatment. Oral glucocorticosteroids may cause systemic side-effects and therefore treatment is often started too late in the hope of a spontaneous recovery. With the introduction of the locally potent glucocorticost...

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Prolonged treatment of pulmonary sarcoidosis with corticosteroids.

The results are described of prolonged corticosteroid treatment in 52 patients with pulmonary sarcoidosis observed for a mean duration of 10-5 years from diagnosis. Twenty of the patients -were treated for less than one year, the remainder for a mean of five years. The mean length of observation after discontinuing treatment was 5*5 years. Selection of patients for treatment was based on (1) ev...

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Inhaled corticosteroids can modulate the immunopathogenesis of pulmonary sarcoidosis.

We investigated the effect of inhaled corticosteroids on the phenotypes and functional capacity of macrophages obtained by bronchoalveolar lavage from patients with pulmonary sarcoidosis. The results were correlated with clinical status and therapeutic efficacy. Ten symptomatic sarcoid patients (previously untreated) with radiological parenchymal shadowing and abnormal pulmonary function receiv...

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Successful treatment of sarcoidosis-associated pulmonary hypertension with corticosteroids.

We report a case of sarcoidosis presenting with cor pulmonale of a greater severity than would be expected from the degree of hypoxia and pulmonary fibrosis. Right heart catheterization revealed that mean pulmonary artery pressure was markedly increased (42 mm Hg), was not reduced by supplemental oxygen, but was reduced significantly (25 mm Hg) after 16 weeks of therapy with corticosteroids. Im...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2005

ISSN: 1465-1858

DOI: 10.1002/14651858.cd001114.pub2